Free Tubulin Modulates Mitochondrial Membrane Potential in Cancer Cells
نویسندگان
چکیده
منابع مشابه
Free tubulin modulates mitochondrial membrane potential in cancer cells.
Formation of the mitochondrial membrane potential (ΔΨ) depends on flux of respiratory substrates, ATP, ADP, and Pi through voltage-dependent anion channels (VDAC). As tubulin promotes single-channel closure of VDAC, we hypothesized that tubulin is a dynamic regulator of ΔΨ, which in cultured cancer cells was assessed by confocal microscopy of the potential-indicating fluorophore tetramethylrhod...
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Formation of the mitochondrial membrane potential (DY) depends on flux of respiratory substrates, ATP, ADP, and Pi through voltage-dependent anion channels (VDAC). As tubulin promotes single-channel closure of VDAC, we hypothesized that tubulin is a dynamic regulator of DY, which in cultured cancer cells was assessed by confocal microscopy of the potential-indicating fluorophore tetramethylrhod...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2010
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-10-2429